Download Neuronal Mechanisms of Memory Formation: Concepts of Long-term Potentiation and Beyond PDF eBook
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Review "...this volume can be recommended for those who wish to succinctly survey the current state of science... This book offers a timely collection of well-written articles..." Timothy J. Teyler, Quarterly Review of Biology Book Description Long-term potentiation (LTP) is by far the most dominant model for neuronal changes that might encode memory. Since the discovery of LTP, researchers have questioned how closely LTP produced in vitro by artificial stimulation of neurons actually models putative learning-induced synaptic changes. A number of recent investigations have tried to correlate these two forms of synaptic plasticity, but have failed to do so.In this book, an international group of neurobiologists and psychologists discuss their latest ideas and data. The results of experiments using electrophysiological techniques in vitro are compared with the results of in vivo experiments. Learning experiments and alternative theoretica l models are also discussed, offering a wide approach.
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Allopregnanolone is synthesized by the reduction of progesterone via the enzymes 5-reductase and 3-hydroxysteroid dehydrogenase (3-HSD). Allopregnanolone is one of the most potent known modulators of GABA receptors. (47,48) Allopregnanolone has behavioral and biochemical characteristics similar to ethanol, barbiturates, and benzodiazepines. (49,50)
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